Non-canonical NFκB mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NFκB pathway

Environmental drug resistance constitutes a serious impediment for therapeutic intervention in multiple myeloma. Tumor-promoting cytokines, such as tumor necrosis factor (TNF), induce nuclear factor-κB (NFκB)- driven expression of pro-survival factors, which confer resistance in myeloma cells to apo...

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Detalles Bibliográficos
Autores principales: Roy, P, Mukherjee, T, Chatterjee, B, Vijayaragavan, B, Banoth, B, Basak, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346295/
https://www.ncbi.nlm.nih.gov/pubmed/27641334
http://dx.doi.org/10.1038/onc.2016.309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346295/
https://www.ncbi.nlm.nih.gov/pubmed/27641334
http://dx.doi.org/10.1038/onc.2016.309

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