A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte

Interleukin-1β (IL-1β) is a pleiotropic cytokine and a crucial mediator of inflammatory and immune responses. IL-1β processing and release are tightly controlled by complex pathways such as NF-kB/ERK1/2, to produce pro-IL-1β, and NALP3/ASC/Caspase-1 inflammasome, to produce the active secreted prote...

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Detalles Bibliográficos
Autores principales: Mezzasoma, Letizia, Antognelli, Cinzia, Talesa, Vincenzo Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346358/
https://www.ncbi.nlm.nih.gov/pubmed/28331244
http://dx.doi.org/10.1155/2017/5858315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346358/
https://www.ncbi.nlm.nih.gov/pubmed/28331244
http://dx.doi.org/10.1155/2017/5858315

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