Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB

Virulent C. difficile toxins TcdA and TcdB invade host intestinal epithelia by endocytosis and use the acidic environment of intracellular vesicles for further processing and activation. We investigated the role of ClC-5, a chloride/proton exchanger expressed in the endosomes of gastrointestinal epi...

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Detalles Bibliográficos
Autores principales: Ruhe, Frederike, Olling, Alexandra, Abromeit, Rasmus, Rataj, Dennis, Grieschat, Matthias, Zeug, Andre, Gerhard, Ralf, Alekov, Alexi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346576/
https://www.ncbi.nlm.nih.gov/pubmed/28348980
http://dx.doi.org/10.3389/fcimb.2017.00067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346576/
https://www.ncbi.nlm.nih.gov/pubmed/28348980
http://dx.doi.org/10.3389/fcimb.2017.00067

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