PICT-1 triggers a pro-death autophagy through inhibiting rRNA transcription and AKT/mTOR/p70S6K signaling pathway

PICT-1 was originally identified as a tumor suppressor. Here, we found that PICT-1 overexpression triggered pro-death autophagy without nucleolar disruption or p53 accumulation in U251 and MCF7 cells. Truncated PICT-1 fragments 181-346 and 1-346, which partly or totally lack nucleolar localization,...

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Detalles Bibliográficos
Autores principales: Chen, Hongbo, Duo, Yanhong, Hu, Bo, Wang, Zhiwei, Zhang, Fang, Tsai, Hsiangi, Zhang, Jianping, Zhou, Lanzhen, Wang, Lijun, Wang, Xinyu, Huang, Laiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346674/
https://www.ncbi.nlm.nih.gov/pubmed/27729611
http://dx.doi.org/10.18632/oncotarget.12288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346674/
https://www.ncbi.nlm.nih.gov/pubmed/27729611
http://dx.doi.org/10.18632/oncotarget.12288

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