Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity

NEK2 is a conserved mitotic regulator critical for cell cycle progression. Aberrant expression of NEK2 has been found in a variety of human cancers, making it an attractive molecular target for the design of novel anticancer therapeutics. In the present study, we have identified a novel compound MBM...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Yanfen, Kong, Yannan, Xi, Jianbei, Zhu, Mengli, Zhu, Tong, Jiang, Tongtong, Frett, Brendan, Hu, Wenhao, Li, Hong-yu, Ma, Mingliang, Zhang, Xiongwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346717/
https://www.ncbi.nlm.nih.gov/pubmed/27764815
http://dx.doi.org/10.18632/oncotarget.12687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346717/
https://www.ncbi.nlm.nih.gov/pubmed/27764815
http://dx.doi.org/10.18632/oncotarget.12687

Ejemplares similares