WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway

The eradication of cancer stem cells (CSCs) is significant for cancer therapy and prevention. In this study, we evaluated WM130, a novel derivative of matrine, for its effect on CSCs using human hepatocellular carcinoma (HCC) cell lines, their sphere cells, and sorted EpCAM(+) cells. We revealed tha...

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Detalles Bibliográficos
Autores principales: Ni, Chen-Xu, Qi, Yang, Zhang, Jin, Liu, Ying, Xu, Wei-Heng, Xu, Jing, Hu, Hong-Gang, Wu, Qiu-Ye, Wang, Yan, Zhang, Jun-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346734/
https://www.ncbi.nlm.nih.gov/pubmed/27783993
http://dx.doi.org/10.18632/oncotarget.12822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346734/
https://www.ncbi.nlm.nih.gov/pubmed/27783993
http://dx.doi.org/10.18632/oncotarget.12822

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