Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models

Intratumoral inoculation of viruses with tumor-selective cytotoxicity may induce cancer cell death and, thereby, shrink neoplastic lesions. It is unlikely, however, that viral tumor cell killing alone could produce meaningful, durable clinical responses, as clinically suitable ‘oncolytic’ viruses ar...

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Detalles Bibliográficos
Autores principales: Holl, Eda K., Brown, Michael C., Boczkowski, David, McNamara, Megan A., George, Daniel J., Bigner, Darell D., Gromeier, Matthias, Nair, Smita K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346754/
https://www.ncbi.nlm.nih.gov/pubmed/27806313
http://dx.doi.org/10.18632/oncotarget.12975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346754/
https://www.ncbi.nlm.nih.gov/pubmed/27806313
http://dx.doi.org/10.18632/oncotarget.12975

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