Cargando…

Antimalarial Properties of Simplified Kalihinol Analogues

[Image: see text] Several kalihinol natural products, members of the broader isocyanoterpene family of antimalarial agents, are potent inhibitors of Plasmodium falciparum, the agent of the most severe form of human malaria. Our previous total synthesis of kalihinol B provided a blueprint to generate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daub, Mary Elisabeth, Prudhomme, Jacques, Ben Mamoun, Choukri, Le Roch, Karine G., Vanderwal, Christopher D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346982/ https://www.ncbi.nlm.nih.gov/pubmed/28337330 http://dx.doi.org/10.1021/acsmedchemlett.7b00013

Ejemplares similares

Synthesis and Potent Antimalarial Activity of Kalihinol B
por: Daub, Mary Elisabeth, et al.
Publicado: (2015)

Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones
por: Clark, Robert D., et al.
Publicado: (2020)

High-content live cell imaging with RNA probes: advancements in high-throughput antimalarial drug discovery
por: Cervantes, Serena, et al.
Publicado: (2009)

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties
por: Urgin, Karène, et al.
Publicado: (2017)

Antimalarial activity of the anticancer and proteasome inhibitor bortezomib and its analog ZL(3)B
por: Reynolds, Jennifer M, et al.
Publicado: (2007)

A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A(1). Evidence for a structural revision
por: Nikolayevskiy, Herman, et al.
Publicado: (2017)

High content live cell imaging for the discovery of new antimalarial marine natural products
por: Cervantes, Serena, et al.
Publicado: (2012)

A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum
por: Le Roch, Karine G, et al.
Publicado: (2008)

3D-QSAR, docking and ADMET properties of aurone analogues as antimalarial agents
por: Hadni, Hanine, et al.
Publicado: (2020)

An Enantiospecific Synthesis of Isoneoamphilectane Confirms Its Strained Tricyclic Structure
por: Dwulet, Natalie C., et al.
Publicado: (2023)

Retargeting azithromycin analogues to have dual-modality antimalarial activity
por: Burns, Amy L., et al.
Publicado: (2020)

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials
por: Cui, Huaqing, et al.
Publicado: (2012)

Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment
por: Mueller, Rudolf, et al.
Publicado: (2020)

Synthesis and Antimalarial Evaluation of Halogenated Analogues of Thiaplakortone A
por: Egbewande, Folake A., et al.
Publicado: (2023)

The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation
por: Chiu, Joy E., et al.
Publicado: (2017)

Treatment of Human Babesiosis: Then and Now
por: Renard, Isaline, et al.
Publicado: (2021)

Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane
por: Blank, Brian R., et al.
Publicado: (2017)

Investigation of Indolglyoxamide and Indolacetamide Analogues of Polyamines as Antimalarial and Antitrypanosomal Agents
por: Wang, Jiayi, et al.
Publicado: (2014)

Robenidine Analogues Are Potent Antimalarials in Drug-Resistant Plasmodium falciparum
por: Krollenbrock, Alina, et al.
Publicado: (2021)

Design, Synthesis and Phenotypic Profiling of Simplified Gedatolisib Analogues
por: Costa, Caroline Marques Xavier, et al.
Publicado: (2023)

Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review
por: Parhizgar, Arezoo Rafiee, et al.
Publicado: (2017)

Herbicidal properties of antimalarial drugs
por: Corral, Maxime G., et al.
Publicado: (2017)

Antimalarial Properties of Dunnione Derivatives as NQO2 Substrates
por: Chhour, Monivan, et al.
Publicado: (2019)

An Alternative Culture Medium for Continuous In Vitro Propagation of the Human Pathogen Babesia duncani in Human Erythrocytes
por: Singh, Pallavi, et al.
Publicado: (2022)

Characterization of the Ubiquitylating Components of the Human Malaria Parasite’s Protein Degradation Pathway
por: Chung, Duk-Won D., et al.
Publicado: (2012)

The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum
por: Bunnik, Evelien M., et al.
Publicado: (2016)

Redesigning therapies for pantothenate kinase–associated neurodegeneration
por: Munshi, Muhammad I., et al.
Publicado: (2022)

Synthesis of a Complex Brasilicardin Analogue Utilizing a Cobalt-Catalyzed MHAT-Induced Radical Bicyclization Reaction
por: Niman, Scott W., et al.
Publicado: (2023)

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum
por: Lu, Xueqing Maggie, et al.
Publicado: (2017)

In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
por: Uche, Fidelia Ijeoma, et al.
Publicado: (2021)

The use of minimal topological differences to inspire the design of novel tetrahydroisoquinoline analogues with antimalarial activity
por: Ngo Hanna, Joelleinsert, et al.
Publicado: (2021)

World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility
por: Bacon, David J, et al.
Publicado: (2007)

Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives
por: Cassagnes, Laure-Estelle, et al.
Publicado: (2017)

Simplified Bryostatin Analogues Protect Cells from Chikungunya Virus-Induced Cell Death
por: Staveness, Daryl, et al.
Publicado: (2016)

DNA-encoded nucleosome occupancy is associated with transcription levels in the human malaria parasite Plasmodium falciparum
por: Bunnik, Evelien M, et al.
Publicado: (2014)

Marine Actinomycetes: A New Source of Compounds against the Human Malaria Parasite
por: Prudhomme, Jacques, et al.
Publicado: (2008)

Development of Simplified Heterocyclic Acetogenin Analogues as Potent and Selective Trypanosoma brucei Inhibitors
por: Florence, Gordon J., et al.
Publicado: (2016)

Maturation of the malarial phosphatidylserine decarboxylase is mediated by high affinity binding to anionic phospholipids
por: Choi, Jae-Yeon, et al.
Publicado: (2023)

Deciphering the Ubiquitin-Mediated Pathway in Apicomplexan Parasites: A Potential Strategy to Interfere with Parasite Virulence
por: Ponts, Nadia, et al.
Publicado: (2008)

The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism
por: Persico, Marco, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dof6u9db3jqflu3s23gc33djui