Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution

The success of targeted cancer therapy is limited by drug resistance that can result from tumor genetic heterogeneity. The current approach to address resistance typically involves initiating a new treatment after clinical/radiographic disease progression, ultimately resulting in futility in most pa...

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Detalles Bibliográficos
Autores principales: Jonsson, Vanessa D., Blakely, Collin M., Lin, Luping, Asthana, Saurabh, Matni, Nikolai, Olivas, Victor, Pazarentzos, Evangelos, Gubens, Matthew A., Bastian, Boris C., Taylor, Barry S., Doyle, John C., Bivona, Trever G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347024/
https://www.ncbi.nlm.nih.gov/pubmed/28287179
http://dx.doi.org/10.1038/srep44206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347024/
https://www.ncbi.nlm.nih.gov/pubmed/28287179
http://dx.doi.org/10.1038/srep44206

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