Characterization of long and stable de novo single alpha-helix domains provides novel insight into their stability

Naturally-occurring single α-helices (SAHs), are rich in Arg (R), Glu (E) and Lys (K) residues, and stabilized by multiple salt bridges. Understanding how salt bridges promote their stability is challenging as SAHs are long and their sequences highly variable. Thus, we designed and tested simple de...

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Detalles Bibliográficos
Autores principales: Wolny, Marcin, Batchelor, Matthew, Bartlett, Gail J., Baker, Emily G., Kurzawa, Marta, Knight, Peter J., Dougan, Lorna, Woolfson, Derek N., Paci, Emanuele, Peckham, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347031/
https://www.ncbi.nlm.nih.gov/pubmed/28287151
http://dx.doi.org/10.1038/srep44341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347031/
https://www.ncbi.nlm.nih.gov/pubmed/28287151
http://dx.doi.org/10.1038/srep44341

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