A new solvate of afatinib, a specific inhibitor of the ErbB family of tyrosine kinases

Afatinib (systematic name: N-{4-(3-chloro-4-fluoro­anilino)-7-[(tetra­hydro­furan-3-yl)­oxy]quinazolin-6-yl}-4-(di­methyl­amino)­but-2-enamide), is a specific in­hibitor of the ErbB family of tyrosine kinases. The free base form crystallizes from aceto­nitrile as a mixed water–aceto­nitrile solvent,...

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Detalles Bibliográficos
Autores principales: Zeller, Matthias, de Araujo, Gabriel Lima Barros, Parker, Trev, Singh Rai, Amrinder, Byrn, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2017
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347068/
https://www.ncbi.nlm.nih.gov/pubmed/28316823
http://dx.doi.org/10.1107/S2056989017002626

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347068/
https://www.ncbi.nlm.nih.gov/pubmed/28316823
http://dx.doi.org/10.1107/S2056989017002626

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