The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes

Type II diabetes (T2D) is characterized by diminished insulin production and resistance of cells to insulin. Among others, endoplasmic reticulum (ER) stress is a principal factor contributing to T2D and induces a shift towards a more reducing cellular environment. At the same time, peripheral insuli...

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Detalles Bibliográficos
Autores principales: Rodriguez Camargo, Diana C., Tripsianes, Konstantinos, Buday, Katalin, Franko, Andras, Göbl, Christoph, Hartlmüller, Christoph, Sarkar, Riddhiman, Aichler, Michaela, Mettenleiter, Gabriele, Schulz, Michael, Böddrich, Annett, Erck, Christian, Martens, Henrik, Walch, Axel Karl, Madl, Tobias, Wanker, Erich E., Conrad, Marcus, de Angelis, Martin Hrabě, Reif, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347123/
https://www.ncbi.nlm.nih.gov/pubmed/28287098
http://dx.doi.org/10.1038/srep44041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347123/
https://www.ncbi.nlm.nih.gov/pubmed/28287098
http://dx.doi.org/10.1038/srep44041

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