CD40-signalling abrogates induction of RORγt(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis

Immune homeostasis in intestinal tissues depends on the generation of regulatory T (Treg) cells. CD103(+) dendritic cells (DCs) acquire microbiota-derived material from the gut lumen for transport to draining lymph nodes and generation of receptor-related orphan γt(+) (RORγt(+)) Helios(−)-induced Tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Barthels, Christian, Ogrinc, Ana, Steyer, Verena, Meier, Stefanie, Simon, Ferdinand, Wimmer, Maria, Blutke, Andreas, Straub, Tobias, Zimber-Strobl, Ursula, Lutgens, Esther, Marconi, Peggy, Ohnmacht, Caspar, Garzetti, Debora, Stecher, Bärbel, Brocker, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347138/
https://www.ncbi.nlm.nih.gov/pubmed/28276457
http://dx.doi.org/10.1038/ncomms14715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347138/
https://www.ncbi.nlm.nih.gov/pubmed/28276457
http://dx.doi.org/10.1038/ncomms14715

Ejemplares similares