Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation

Parkin and PINK1 function in a common pathway to clear damaged mitochondria. Parkin exists in an auto-inhibited conformation stabilized by multiple interdomain interactions. The binding of PINK1-generated phospho-ubiquitin and the phosphorylation of the ubiquitin-like (Ubl) domain of Parkin at Ser65...

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Detalles Bibliográficos
Autores principales: Tang, Matthew Y., Vranas, Marta, Krahn, Andrea I., Pundlik, Shayal, Trempe, Jean- François, Fon, Edward A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347139/
https://www.ncbi.nlm.nih.gov/pubmed/28276439
http://dx.doi.org/10.1038/ncomms14697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347139/
https://www.ncbi.nlm.nih.gov/pubmed/28276439
http://dx.doi.org/10.1038/ncomms14697

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