Cargando…

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

The purpose of this study was to elucidate the mechanisms associated with the specific effects of AKT1 and AKT2 isoforms in breast cancer progression. We modulated the abundance of specific AKT isoforms in IBH-6 and T47D human breast cancer cell lines and showed that AKT1 promoted cell proliferation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Riggio, Marina, Perrone, María C., Polo, María L., Rodriguez, María J., May, María, Abba, Martín, Lanari, Claudia, Novaro, Virginia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347151/ https://www.ncbi.nlm.nih.gov/pubmed/28287129 http://dx.doi.org/10.1038/srep44244

Ejemplares similares

Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression
por: Polo, María Laura, et al.
Publicado: (2015)

Responsiveness to PI3K and MEK Inhibitors in Breast Cancer. Use of a 3D Culture System to Study Pathways Related to Hormone Independence in Mice
por: Polo, Maria Laura, et al.
Publicado: (2010)

Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease
por: Reyes-Gordillo, Karina, et al.
Publicado: (2019)

Akt isoform specific effects in ovarian cancer progression
por: Linnerth-Petrik, Nicolle M., et al.
Publicado: (2016)

The BA-BCS 2021: An Initial “Trial” for Integrating Basic Science and Medical Progress on Breast Cancer in a Latin-American Country
por: Kordon, Edith, et al.
Publicado: (2021)

AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity
por: Levenga, Josien, et al.
Publicado: (2017)

Distinct functions of AKT isoforms in breast cancer: a comprehensive review
por: Hinz, Nico, et al.
Publicado: (2019)

Akt isoforms in vascular disease
por: Yu, Haixiang, et al.
Publicado: (2015)

Akt isoforms in the immune system
por: Guerau-de-Arellano, Mireia, et al.
Publicado: (2022)

Opposing Functions of Akt Isoforms in Lung Tumor Initiation and Progression
por: Linnerth-Petrik, Nicolle M., et al.
Publicado: (2014)

Isoform specificity of progesterone receptor antibodies
por: Fabris, Victoria, et al.
Publicado: (2017)

AKT2 is the predominant AKT isoform expressed in human skeletal muscle
por: Matheny, Ronald W., et al.
Publicado: (2018)

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity
por: Lee, Rachel S., et al.
Publicado: (2011)

The AKT1 isoform plays a dominant role in the survival and chemoresistance of chronic lymphocytic leukaemia cells
por: Hofbauer, Sebastian W., et al.
Publicado: (2015)

AKT isoform-specific expression and activation across cancer lineages
por: Wang, Jue, et al.
Publicado: (2018)

Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma
por: Roy, Nand Kishor, et al.
Publicado: (2019)

AS101 Prevents Diabetic Nephropathy Progression and Mesangial Cell Dysfunction: Regulation of the AKT Downstream Pathway
por: Shemesh, Itay Israel, et al.
Publicado: (2014)

All Akt Isoforms (Akt1, Akt2, Akt3) Are Involved in Normal Hearing, but Only Akt2 and Akt3 Are Involved in Auditory Hair Cell Survival in the Mammalian Inner Ear
por: Brand, Yves, et al.
Publicado: (2015)

Targeting mTOR to overcome resistance to hormone and CDK4/6 inhibitors in ER-positive breast cancer models
por: Rodriguez, María Jimena, et al.
Publicado: (2023)

Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model
por: Saji, Motoyasu, et al.
Publicado: (2020)

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer
por: Virtakoivu, Reetta, et al.
Publicado: (2012)

Development and characterization of protein kinase B/AKT isoform-specific nanobodies
por: Merckaert, Tijs, et al.
Publicado: (2020)

The Akt1 isoform is an essential mediator of ischaemic preconditioning
por: Kunuthur, Suma P, et al.
Publicado: (2012)

Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐Selectivity
por: Quambusch, Lena, et al.
Publicado: (2019)

Akt Isoforms: A Family Affair in Breast Cancer
por: Basu, Alakananda, et al.
Publicado: (2021)

Akt isoforms differentially provide for chemoresistance in prostate cancer
por: Ma, Bo, et al.
Publicado: (2022)

Akt (protein kinase B) isoform phosphorylation and signaling downstream of mTOR (mammalian target of rapamycin) in denervated atrophic and hypertrophic mouse skeletal muscle
por: Norrby, Marlene, et al.
Publicado: (2012)

Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts
por: Wickenden, Julie A, et al.
Publicado: (2010)

Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis
por: Lee, Jong-Ho, et al.
Publicado: (2017)

Cellular model system to dissect the isoform-selectivity of Akt inhibitors
por: Quambusch, Lena, et al.
Publicado: (2021)

Differential activation of AKT isoforms by growth factors in human myotubes
por: Roberts, Brandon M., et al.
Publicado: (2023)

Immunohistological Examination of AKT Isoforms in the Brain: Cell-Type Specificity That May Underlie AKT’s Role in Complex Brain Disorders and Neurological Disease
por: Levenga, Josien, et al.
Publicado: (2021)

Development of a new model system to dissect isoform specific Akt signalling in adipocytes
por: Kajno, Esi, et al.
Publicado: (2015)

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt
por: Blaustein, Matías, et al.
Publicado: (2021)

Beneficial Effects of Mifepristone Treatment in Patients with Breast Cancer Selected by the Progesterone Receptor Isoform Ratio: Results from the MIPRA Trial
por: Elía, Andrés, et al.
Publicado: (2023)

Myosin II isoforms play distinct roles in adherens junction biogenesis
por: Heuzé, Mélina L, et al.
Publicado: (2019)

The effectiveness of nano chemotherapeutic particles combined with mifepristone depends on the PR isoform ratio in preclinical models of breast cancer
por: Sequeira, Gonzalo, et al.
Publicado: (2014)

Conditional inactivation of Akt three isoforms causes tau hyperphosphorylation in the brain
por: Wang, Long, et al.
Publicado: (2015)

Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas
por: Dobashi, Yoh, et al.
Publicado: (2015)

Prognostic value of AKT isoforms in non-small cell lung adenocarcinoma
por: Khurana, Sahil, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5imu7inc67bpe3ofikik8h9vvo