Killing of Staphylococcus aureus and Salmonella enteritidis and neutralization of lipopolysaccharide by 17-residue bovine lactoferricins: improved activity of Trp/Ala-containing molecules

Bovine lactoferricin (LfcinB) has potent antibacterial, antifungal and antiparasitic activities but is also hemolytic. Our objective was to identify LfcinB17-31 derivatives with reduced hemolysis and improved antimicrobial activity via substituting Cys3, Arg4, Gln7, Met10, and Gly14 with more hydrop...

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Detalles Bibliográficos
Autores principales: Hao, Ya, Yang, Na, Wang, Xiumin, Teng, Da, Mao, Ruoyu, Wang, Xiao, Li, Zhanzhan, Wang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347165/
https://www.ncbi.nlm.nih.gov/pubmed/28287172
http://dx.doi.org/10.1038/srep44278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347165/
https://www.ncbi.nlm.nih.gov/pubmed/28287172
http://dx.doi.org/10.1038/srep44278

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