Small Molecule-Induced Domain Swapping as a Mechanism for Controlling Protein Function and Assembly

Domain swapping is the process by which identical proteins exchange reciprocal segments to generate dimers. Here we introduce induced domain swapping (INDOS) as a mechanism for regulating protein function. INDOS employs a modular design consisting of the fusion of two proteins: a recognition protein...

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Detalles Bibliográficos
Autores principales: Karchin, Joshua M., Ha, Jeung-Hoi, Namitz, Kevin E., Cosgrove, Michael S., Loh, Stewart N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347425/
https://www.ncbi.nlm.nih.gov/pubmed/28287617
http://dx.doi.org/10.1038/srep44388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347425/
https://www.ncbi.nlm.nih.gov/pubmed/28287617
http://dx.doi.org/10.1038/srep44388

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