SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling

SOX9 inactivation is frequent in colorectal cancer (CRC) due to SOX9 gene mutations and/or to ectopic expression of MiniSOX9, a dominant negative inhibitor of SOX9. In the present study, we report a heterozygous L142P inactivating mutation of SOX9 in the DLD-1 CRC cell line and we demonstrate that t...

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Detalles Bibliográficos
Autores principales: Prévostel, Corinne, Rammah-Bouazza, Cyrine, Trauchessec, Hélène, Canterel-Thouennon, Lucile, Busson, Muriel, Ychou, Marc, Blache, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347687/
https://www.ncbi.nlm.nih.gov/pubmed/27429045
http://dx.doi.org/10.18632/oncotarget.10573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347687/
https://www.ncbi.nlm.nih.gov/pubmed/27429045
http://dx.doi.org/10.18632/oncotarget.10573

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