Cargando…

Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells

The phosphatidylinositol-3 kinase (PI3K)/Akt/mTOR signaling pathway is activated in many human cancers. Previously, we reported that patients with early stage cervical cancer whose tumours harbour PIK3CA exon 9 or 20 mutations have worse overall survival in response to treatment with radiation and c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arjumand, Wani, Merry, Cole D., Wang, Chen, Saba, Elias, McIntyre, John B., Fang, Shujuan, Kornaga, Elizabeth, Ghatage, Prafull, Doll, Corinne M., Lees, Susan P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347702/ https://www.ncbi.nlm.nih.gov/pubmed/27489350 http://dx.doi.org/10.18632/oncotarget.10955

Ejemplares similares

Roles of phosphatidyl inositol 3 kinase gamma (PI3Kγ) in respiratory diseases
por: Sala, Valentina, et al.
Publicado: (2021)

Clinical significance of Phosphatidyl Inositol Synthase overexpression in oral cancer
por: Kaur, Jatinder, et al.
Publicado: (2010)

Anemia, leukocytosis and thrombocytosis as prognostic factors in patients with cervical cancer treated with radical chemoradiotherapy: A retrospective cohort study
por: Koulis, Theodora A., et al.
Publicado: (2017)

Mutations in the inositol polyphosphate-5-phosphatase E gene link phosphatidyl inositol signaling to the ciliopathies
por: Bielas, Stephanie L., et al.
Publicado: (2009)

Topical application of phosphatidyl-inositol-3,5-bisphosphate for acute lung injury in neonatal swine
por: Preuß, Stefanie, et al.
Publicado: (2012)

Clozapine Interaction with Phosphatidyl Inositol 3-Kinase (PI3K)/Insulin Signaling Pathway in Caenorhabditis elegans
por: Karmacharya, Rakesh, et al.
Publicado: (2009)

BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma
por: Speranza, Maria-Carmela, et al.
Publicado: (2016)

Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis
por: Wu, Zuoxing, et al.
Publicado: (2023)

Fas-Induced Apoptosis of Human Neutrophils is Promoted by Phosphatidyl Inositol 3-Kinase but Suppressed by P38-MAPK Activity
por: Alvarado-Kristensson, Maria, et al.
Publicado: (2001)

Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain
por: Arroyo, Daniela S., et al.
Publicado: (2018)

Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations
por: Leontiadou, Hari, et al.
Publicado: (2018)

Prevalence and prognostic role of PIK3CA E545K mutation in Iranian colorectal cancer patients
por: Ranjbar, Reza, et al.
Publicado: (2019)

The Impact of Glycosyl-Phosphatidyl-Inositol Anchored MICA Alleles on Novel NKG2D-Based Therapies
por: Valés-Gómez, Mar
Publicado: (2015)

The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR
por: Zhao, Shuai, et al.
Publicado: (2016)

The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia
por: Allegretti, Matteo, et al.
Publicado: (2015)

Understanding the Mannose Transfer Mechanism of Mycobacterial Phosphatidyl-myo-inositol Mannosyltransferase A from Molecular Dynamics Simulations
por: Bhattacharje, Gourab, et al.
Publicado: (2022)

Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3β in a hamster model of oral oncogenesis
por: Sophia, Josephraj, et al.
Publicado: (2016)

Determination of pH Effects on Phosphatidyl-Hydroxytyrosol and Phosphatidyl-Tyrosol Bilayer Behavior
por: Evans, Kervin O., et al.
Publicado: (2018)

Targeted inhibition of phosphatidyl inositol-3-kinase p110β, but not p110α, enhances apoptosis and sensitivity to paclitaxel in chemoresistant ovarian cancers
por: Jeong, Ju-yeon, et al.
Publicado: (2013)

Erratum: The pan-class I phosphatidyl-inositol-3 kinase inhibitor NVP-BKM120 demonstrates anti-leukemic activity in acute myeloid leukemia
por: Allegretti, Matteo, et al.
Publicado: (2016)

Conserved RNA Binding Activity of Phosphatidyl Inositol 5-Phosphate 4-Kinase (PIP4K2A)
por: Behari, Jatin, et al.
Publicado: (2021)

The sensitivity and efficacy method of PIK3CA exon 9 E545A as a high diagnostic accuracy in breast cancer
por: Desriani, et al.
Publicado: (2018)

Induction of Apoptosis Scutellaria baicalensis Georgi Root Extract by Inactivation of the Phosphatidyl Inositol 3-kinase/Akt Signaling Pathway in Human Leukemia U937 Cells
por: Choi, Eun Ok, et al.
Publicado: (2019)

Acceptor Substrate Discrimination in Phosphatidyl-myo-inositol Mannoside Synthesis: STRUCTURAL AND MUTATIONAL ANALYSIS OF MANNOSYLTRANSFERASE CORYNEBACTERIUM GLUTAMICUM PimB′
por: Batt, Sarah M., et al.
Publicado: (2010)

Glycosyl-Phosphatidyl-Inositol (GPI)-Anchors and Metalloproteases: Their Roles in the Regulation of Exosome Composition and NKG2D-Mediated Immune Recognition
por: López-Cobo, Sheila, et al.
Publicado: (2016)

PHYSICAL STUDIES OF PHOSPHOLIPIDS : III. Electron Microscope Studies of Some Pure Fully Saturated 2,3-Diacyl-DL-Phosphatidyl-Ethanolamines and Phosphatidyl-Cholines
por: Chapman, D., et al.
Publicado: (1966)

Development of a Human Breast-Cancer Derived Cell Line Stably Expressing a Bioluminescence Resonance Energy Transfer (BRET)-Based Phosphatidyl Inositol-3 Phosphate (PIP(3)) Biosensor
por: Kuo, Mei-Shiue, et al.
Publicado: (2014)

Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
por: Centola, Martin, et al.
Publicado: (2021)

Phosphatidyl Inositol 3 Kinase-Gamma Balances Antiviral and Inflammatory Responses During Influenza A H1N1 Infection: From Murine Model to Genetic Association in Patients
por: Garcia, Cristiana C., et al.
Publicado: (2018)

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R
por: Meyer, D S, et al.
Publicado: (2013)

The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer
por: Jiang, Wei, et al.
Publicado: (2018)

Mucinous Cancer of the Ovary: Overview and Current Status
por: Babaier, Abdulaziz, et al.
Publicado: (2020)

Etiology, Clinical Features, and Diagnosis of Vulvar Lichen Sclerosus: A Scoping Review
por: Singh, Nilanchali, et al.
Publicado: (2020)

Among patients with advanced ovarian carcinoma, who benefits from bevacizumab the most?
por: Babaier, Abdulaziz, et al.
Publicado: (2023)

Introduction and expression of PIK3CA(E545K) in a papillary thyroid cancer BRAF(V600E) cell line leads to a dedifferentiated aggressive phenotype
por: Pinto, Nicole, et al.
Publicado: (2022)

Treatment Options in Vulvar Lichen Sclerosus: A Scoping Review
por: Singh, Nilanchali, et al.
Publicado: (2021)

Past, Present, and Future of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer
por: Mishra, Mona, et al.
Publicado: (2021)

Role of Phosphatidyl-Serine in Bone Repair and Its Technological Exploitation
por: Merolli, Antonio, et al.
Publicado: (2009)

Facile Synthesis of Phosphatidyl Saccharides for Preparation of Anionic Nanoliposomes with Enhanced Stability
por: Song, Shuang, et al.
Publicado: (2013)

Cerebrovascular events in patients with isolated anti-phosphatidyl-serine/prothrombin antibodies
por: Radin, Massimo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tklk2vu1ef3mln5ngsronvqj5a