Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model

The marine environment constitutes an extraordinary resource for the discovery of new therapeutic agents. In the present manuscript we studied the effect of 3 different sponge derived guanidine alkaloids, crambescidine-816, -830, and -800. We show that these compounds strongly inhibit tumor cell pro...

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Detalles Bibliográficos
Autores principales: Roel, María, Rubiolo, Juan A., Guerra-Varela, Jorge, Silva, Siguara B. L., Thomas, Olivier P., Cabezas-Sainz, Pablo, Sánchez, Laura, López, Rafael, Botana, Luis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347754/
https://www.ncbi.nlm.nih.gov/pubmed/27825113
http://dx.doi.org/10.18632/oncotarget.13068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347754/
https://www.ncbi.nlm.nih.gov/pubmed/27825113
http://dx.doi.org/10.18632/oncotarget.13068

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