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Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model
The marine environment constitutes an extraordinary resource for the discovery of new therapeutic agents. In the present manuscript we studied the effect of 3 different sponge derived guanidine alkaloids, crambescidine-816, -830, and -800. We show that these compounds strongly inhibit tumor cell pro...
Autores principales: | Roel, María, Rubiolo, Juan A., Guerra-Varela, Jorge, Silva, Siguara B. L., Thomas, Olivier P., Cabezas-Sainz, Pablo, Sánchez, Laura, López, Rafael, Botana, Luis M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347754/ https://www.ncbi.nlm.nih.gov/pubmed/27825113 http://dx.doi.org/10.18632/oncotarget.13068 |
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