SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors

PURPOSE: We have previously shown that supraoptimal signaling of high avidity T cells leads to high expression of PD-1 and inhibition of proliferation. This study was designed to see if this effect could be mitigated by combining a vaccine that stimulates high avidity T cells with PD-1 blockade. EXP...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Wei, Brentville, Victoria A., Symonds, Peter, Cook, Katherine W., Yagita, Hideo, Metheringham, Rachael L., Durrant, Lindy G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347755/
https://www.ncbi.nlm.nih.gov/pubmed/27825115
http://dx.doi.org/10.18632/oncotarget.13070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347755/
https://www.ncbi.nlm.nih.gov/pubmed/27825115
http://dx.doi.org/10.18632/oncotarget.13070

Ejemplares similares