O-glycan sialylation alters galectin-3 subcellular localization and decreases chemotherapy sensitivity in gastric cancer

ST6GalNAc-I, the sialyltransferase responsible for sialyl-Tn (sTn) synthesis, has been previously reported to be positively associated with cancer aggressiveness. Here we describe a novel sTn-dependent mechanism for chemotherapeutic resistance. We show that sTn protects cancer cells against chemothe...

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Detalles Bibliográficos
Autores principales: Santos, Sofia N., Junqueira, Mara S., Francisco, Guilherme, Vilanova, Manuel, Magalhães, Ana, Baruffi, Marcelo Dias, Chammas, Roger, Harris, Adrian L., Reis, Celso A., Bernardes, Emerson S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347789/
https://www.ncbi.nlm.nih.gov/pubmed/27835877
http://dx.doi.org/10.18632/oncotarget.13192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347789/
https://www.ncbi.nlm.nih.gov/pubmed/27835877
http://dx.doi.org/10.18632/oncotarget.13192

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