Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects

BACKGROUND: Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron’s principal cells. In a dose-response study, we measured the effect of tolvaptan on renal handling of water and sodium and syste...

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Detalles Bibliográficos
Autores principales: Al Therwani, Safa, Rosenbæk, Jeppe Bakkestrøm, Mose, Frank Holden, Bech, Jesper Nørgaard, Pedersen, Erling Bjerregaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347830/
https://www.ncbi.nlm.nih.gov/pubmed/28288570
http://dx.doi.org/10.1186/s12882-017-0501-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347830/
https://www.ncbi.nlm.nih.gov/pubmed/28288570
http://dx.doi.org/10.1186/s12882-017-0501-1

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