Cargando…

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets

ESSENTIALS: Dimeric high‐affinity collagen receptor glycoprotein VI (GPVI) is present on resting platelets. Spatio‐temporal organization of platelet GPVI‐dimers was evaluated using advanced microscopy. Upon platelet adhesion to collagenous substrates, GPVI‐dimers coalesce to form clusters. Clusterin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P., Jung, S. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	PLATELETS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347898/ https://www.ncbi.nlm.nih.gov/pubmed/28058806 http://dx.doi.org/10.1111/jth.13613

Ejemplares similares

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation
por: Jooss, Natalie J., et al.
Publicado: (2022)

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood
por: Jung, Stephanie M., et al.
Publicado: (2012)

Platelet collagen receptor Glycoprotein VI‐dimer recognizes fibrinogen and fibrin through their D‐domains, contributing to platelet adhesion and activation during thrombus formation
por: Induruwa, I., et al.
Publicado: (2018)

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2
por: HUGHES, C E, et al.
Publicado: (2008)

Non-genomic effects of PPARγ ligands: inhibition of GPVI-stimulated platelet activation
por: Moraes, L A, et al.
Publicado: (2010)

GPVI expression is linked to platelet size, age, and reactivity
por: Veninga, Alicia, et al.
Publicado: (2022)

Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition
por: Billiald, Philippe, et al.
Publicado: (2022)

Procoagulant platelet sentinels prevent inflammatory bleeding through GPIIBIIIA and GPVI
por: Kaiser, Rainer, et al.
Publicado: (2022)

Identification of a major GpVI-binding locus in human type III collagen
por: Jarvis, Gavin E., et al.
Publicado: (2008)

Evaluation of the effect of eltrombopag therapy on the platelet collagen receptor glycoprotein VI (GPVI) expression and soluble GPVI levels in young patients with immune thrombocytopenia
por: Tantawy, Azza Abdel Gawad, et al.
Publicado: (2022)

Factor XIII is a newly identified binding partner for platelet collagen receptor GPVI‐dimer—An interaction that may modulate fibrin crosslinking
por: Moroi, Masaaki, et al.
Publicado: (2022)

Platelet GPVI (Glycoprotein VI) and Thrombotic Complications in the Venous System
por: Perrella, Gina, et al.
Publicado: (2021)

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation
por: Neagoe, Raluca A. I., et al.
Publicado: (2022)

Differential Inhibition of Human Atherosclerotic Plaque–Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies
por: Jamasbi, Janina, et al.
Publicado: (2015)

Targeting GPVI as a novel antithrombotic strategy
por: Andrews, Robert K, et al.
Publicado: (2014)

Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation
por: Dunster, Joanne L., et al.
Publicado: (2019)

GPVI (Glycoprotein VI) Interaction With Fibrinogen Is Mediated by Avidity and the Fibrinogen αC-Region
por: Xu, Rui-Gang, et al.
Publicado: (2021)

Comparison of the GPVI inhibitors losartan and honokiol
por: Onselaer, Marie-Blanche, et al.
Publicado: (2019)

Characterization of GPVI- or GPVI-CD39-Coated Nanoparticles and Their Impact on In Vitro Thrombus Formation
por: Nestele, Jeremy A., et al.
Publicado: (2021)

Modified platelet deposition on matrix metalloproteinase 13 digested collagen I
por: Howes, J.‐M., et al.
Publicado: (2015)

Dimeric FcγR ectodomains detect pathogenic anti‐platelet factor 4–heparin antibodies in heparin‐induced thromobocytopenia
por: Wines, B. D., et al.
Publicado: (2018)

The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors
por: Koo, Chek Ziu, et al.
Publicado: (2022)

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation
por: Haining, Elizabeth J., et al.
Publicado: (2016)

Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion
por: Leatherdale, Alexander, et al.
Publicado: (2020)

Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity
por: Barrachina, María N., et al.
Publicado: (2019)

Cleavage by MMP‐13 renders VWF unable to bind to collagen but increases its platelet reactivity
por: Howes, Joanna‐Marie, et al.
Publicado: (2020)

Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation
por: Akbar, Huzoor, et al.
Publicado: (2011)

The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis
por: Sasikumar, P., et al.
Publicado: (2018)

The GPIbα intracellular tail - role in transducing VWF- and collagen/GPVI-mediated signaling
por: Constantinescu-Bercu, Adela, et al.
Publicado: (2021)

mTOR regulates GPVI-mediated platelet activation
por: Wang, Longsheng, et al.
Publicado: (2021)

GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity
por: Barrachina, María N., et al.
Publicado: (2019)

Discovery of Novel GPVI Receptor Antagonists by Structure-Based Repurposing
por: Taylor, Lewis, et al.
Publicado: (2014)

Human Platelet Protein Ubiquitylation and Changes following GPVI Activation
por: Unsworth, Amanda J., et al.
Publicado: (2019)

Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny
por: Valenzuela, Allan, et al.
Publicado: (2023)

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice
por: Eaton, Nathan, et al.
Publicado: (2020)

Ablation of collagen VI leads to the release of platelets with altered function
por: Abbonante, Vittorio, et al.
Publicado: (2021)

MMP‐13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation
por: Howes, Joanna‐Marie, et al.
Publicado: (2018)

Akt and mitogen‐activated protein kinase enhance C‐type lectin‐like receptor 2‐mediated platelet activation by inhibition of glycogen synthase kinase 3α/β
por: Moroi, A. J., et al.
Publicado: (2015)

Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease
por: Pennings, Gabrielle J., et al.
Publicado: (2023)

Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling
por: Judd, Barbi A., et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_8csuab1rh5k2gif8pilu4gong1