MEK1 is required for the development of NRAS-driven leukemia

The dual-specificity kinases MEK1 and MEK2 act downstream of RAS/RAF to induce ERK activation, which is generally considered protumorigenic. Activating MEK mutations have not been discovered in leukemia, in which pathway activation is caused by mutations in upstream components such as RAS or Flt3. T...

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Detalles Bibliográficos
Autores principales: Nowacka, Joanna D., Baumgartner, Christian, Pelorosso, Cristiana, Roth, Mareike, Zuber, Johannes, Baccarini, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348309/
https://www.ncbi.nlm.nih.gov/pubmed/27741509
http://dx.doi.org/10.18632/oncotarget.12555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348309/
https://www.ncbi.nlm.nih.gov/pubmed/27741509
http://dx.doi.org/10.18632/oncotarget.12555

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