Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing

The GLI genes are transcription factors and in cancers are oncogenes, aberrantly and constitutively activated. GANT61, a specific GLI inhibitor, has induced extensive cytotoxicity in human models of colon cancer. The FOXM1 promoter was determined to be a transcriptional target of GLI1. In HT29 cells...

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Detalles Bibliográficos
Autores principales: Zhang, Ruowen, Wu, Jiahui, Ferrandon, Sylvain, Glowacki, Katie J., Houghton, Janet A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348313/
https://www.ncbi.nlm.nih.gov/pubmed/27863397
http://dx.doi.org/10.18632/oncotarget.13376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348313/
https://www.ncbi.nlm.nih.gov/pubmed/27863397
http://dx.doi.org/10.18632/oncotarget.13376

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