The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression

Pygo2 acts as a co-activator of Wnt signaling in a nuclear complex with ß-catenin/BCL9/BCL9-2 to increase target gene transcription. Previous studies showed that Pygo2 is upregulated in murine intestinal tumors and human colon cancer, but is apparently dispensable for normal intestinal homeostasis....

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Detalles Bibliográficos
Autores principales: Talla, Suranand B., Brembeck, Felix H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348345/
https://www.ncbi.nlm.nih.gov/pubmed/27811361
http://dx.doi.org/10.18632/oncotarget.13016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348345/
https://www.ncbi.nlm.nih.gov/pubmed/27811361
http://dx.doi.org/10.18632/oncotarget.13016

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