Cargando…
The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression
Pygo2 acts as a co-activator of Wnt signaling in a nuclear complex with ß-catenin/BCL9/BCL9-2 to increase target gene transcription. Previous studies showed that Pygo2 is upregulated in murine intestinal tumors and human colon cancer, but is apparently dispensable for normal intestinal homeostasis....
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348345/ https://www.ncbi.nlm.nih.gov/pubmed/27811361 http://dx.doi.org/10.18632/oncotarget.13016 |