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Hmgb1 inhibits Klotho expression and malignant phenotype in melanoma cells by activating NF-κB

The molecular and cellular mechanisms behind the involvement of inflammation in melanoma have not been fully elucidated. In this study, knockdown of Hmgb1 expression increased apoptosis, reduced invasion and p-NF-κB expression, but increased Klotho protein level in melanoma tumor cells. The effect o...

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Detalles Bibliográficos
Autores principales: Xie, Biao, Cao, Ke, Li, Jinjin, Chen, Jia, Tang, Jintian, Chen, Xiang, Xia, Kun, Zhou, Xiao, Cheng, Yan, Zhou, Jianda, Xie, Huiqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348353/
https://www.ncbi.nlm.nih.gov/pubmed/27779100
http://dx.doi.org/10.18632/oncotarget.12623