TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic “Achilles heel” for the TrkAIII oncoprotein in neuroblastoma

TrkAIII expression in neuroblastoma (NB) associates with advanced stage disease, worse prognosis, post therapeutic relapse, and in NB models TrkAIII exhibits oncogenic activity and promotes chemotherapeutic-resistance. Here, we report a potential therapeutic “Achilles heel” for the TrkAIII oncoprote...

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Detalles Bibliográficos
Autores principales: Gneo, Luciana, Ruggeri, Pierdomenico, Cappabianca, Lucia, Farina, Antonietta Rosella, Ianni, Natalia Di, Mackay, Andrew Reay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348358/
https://www.ncbi.nlm.nih.gov/pubmed/27821809
http://dx.doi.org/10.18632/oncotarget.13098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348358/
https://www.ncbi.nlm.nih.gov/pubmed/27821809
http://dx.doi.org/10.18632/oncotarget.13098

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