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PC-1 works in conjunction with E3 ligase CHIP to regulate androgen receptor stability and activity
The androgen receptor (AR) is not only a ligand-dependent transcription factor, but also functions as a licensing factor, a component of DNA replication, which is degraded during mitosis. Furthermore, the deregulation of AR activity is involved in the initiation of prostate cancer and contributes to...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348399/ https://www.ncbi.nlm.nih.gov/pubmed/27835608 http://dx.doi.org/10.18632/oncotarget.13230 |