Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants—Genotype to Cellular Phenotype

Dilated Cardiomyopathy (DCM) is a leading cause of sudden cardiac death characterized by impaired pump function and dilatation of cardiac ventricles. In this review we discuss various in silico approaches to elucidating the mechanisms of genetic mutations leading to DCM. The approaches covered in th...

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Detalles Bibliográficos
Autores principales: Dewan, Sukriti, McCabe, Kimberly J., Regnier, Michael, McCulloch, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348544/
https://www.ncbi.nlm.nih.gov/pubmed/28352236
http://dx.doi.org/10.3389/fphys.2017.00151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348544/
https://www.ncbi.nlm.nih.gov/pubmed/28352236
http://dx.doi.org/10.3389/fphys.2017.00151

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