mTOR inhibitors in the pharmacologic management of tuberous sclerosis complex and their potential role in other rare neurodevelopmental disorders

Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder that affects multiple organ systems throughout the body. Dysregulation of the mammalian target of rapamycin (mTOR) pathway is implicated in the disease pathology, and evidence exists to support the use of mTOR inhibitors...

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Detalles Bibliográficos
Autores principales: Franz, David N., Capal, Jamie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348752/
https://www.ncbi.nlm.nih.gov/pubmed/28288694
http://dx.doi.org/10.1186/s13023-017-0596-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348752/
https://www.ncbi.nlm.nih.gov/pubmed/28288694
http://dx.doi.org/10.1186/s13023-017-0596-2

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