Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats

BACKGROUND: Axon development plays a pivotal role in the formation of synapse, nodes of Ranvier, and myelin sheath. Interleukin-1β (IL-1β) produced by microglia may cause myelination disturbances through suppression of oligodendrocyte progenitor cell maturation in the septic neonatal rats. Here, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Qianpeng, Lin, Qiongyu, Huang, Peixian, Chen, Mengmeng, Hu, Xin, Fu, Hui, He, Shaoru, Shen, Fengcai, Zeng, Hongke, Deng, Yiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348817/
https://www.ncbi.nlm.nih.gov/pubmed/28288671
http://dx.doi.org/10.1186/s12974-017-0805-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348817/
https://www.ncbi.nlm.nih.gov/pubmed/28288671
http://dx.doi.org/10.1186/s12974-017-0805-x

Ejemplares similares