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Microglia-derived IL-1β contributes to axon development disorders and synaptic deficit through p38-MAPK signal pathway in septic neonatal rats

BACKGROUND: Axon development plays a pivotal role in the formation of synapse, nodes of Ranvier, and myelin sheath. Interleukin-1β (IL-1β) produced by microglia may cause myelination disturbances through suppression of oligodendrocyte progenitor cell maturation in the septic neonatal rats. Here, we...

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Detalles Bibliográficos
Autores principales:	Han, Qianpeng, Lin, Qiongyu, Huang, Peixian, Chen, Mengmeng, Hu, Xin, Fu, Hui, He, Shaoru, Shen, Fengcai, Zeng, Hongke, Deng, Yiyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348817/ https://www.ncbi.nlm.nih.gov/pubmed/28288671 http://dx.doi.org/10.1186/s12974-017-0805-x

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