Endothelial Dll4 overexpression reduces vascular response and inhibits tumor growth and metastasization in vivo

BACKGROUND: The inhibition of Delta-like 4 (Dll4)/Notch signaling has been shown to result in excessive, nonfunctional vessel proliferation and significant tumor growth suppression. However, safety concerns emerged with the identification of side effects resulting from chronic Dll4/Notch blockade. A...

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Detalles Bibliográficos
Autores principales: Trindade, Alexandre, Djokovic, Dusan, Gigante, Joana, Mendonça, Liliana, Duarte, António
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348880/
https://www.ncbi.nlm.nih.gov/pubmed/28288569
http://dx.doi.org/10.1186/s12885-017-3171-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348880/
https://www.ncbi.nlm.nih.gov/pubmed/28288569
http://dx.doi.org/10.1186/s12885-017-3171-2

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