Conserved residues within the HIV-1 Vpu transmembrane-proximal hinge region modulate BST2 binding and antagonism

BACKGROUND: BST2 inhibits HIV-1 release by tethering nascent virions to the surface of infected cells. HIV-1 Vpu overcomes this restriction by removing BST2 from viral budding sites via BST2 intracellular trapping and sequestration, surface downregulation and/or displacement mechanisms. Vpu is compo...

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Detalles Bibliográficos
Autores principales: Lukhele, Sabelo, Cohen, Éric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348903/
https://www.ncbi.nlm.nih.gov/pubmed/28288652
http://dx.doi.org/10.1186/s12977-017-0345-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348903/
https://www.ncbi.nlm.nih.gov/pubmed/28288652
http://dx.doi.org/10.1186/s12977-017-0345-6

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