Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism

Mutations in nuclear genes associated with defective coenzyme A biosynthesis have been identified as responsible for some forms of neurodegeneration with brain iron accumulation (NBIA), namely PKAN and CoPAN. PKAN are defined by mutations in PANK2, encoding the pantothenate kinase 2 enzyme, that acc...

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Detalles Bibliográficos
Autores principales: Ceccatelli Berti, Camilla, Dallabona, Cristina, Lazzaretti, Mirca, Dusi, Sabrina, Tosi, Elena, Tiranti, Valeria, Goffrini, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348974/
https://www.ncbi.nlm.nih.gov/pubmed/28357284
http://dx.doi.org/10.15698/mic2015.04.196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348974/
https://www.ncbi.nlm.nih.gov/pubmed/28357284
http://dx.doi.org/10.15698/mic2015.04.196

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