Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast

Impaired protein degradation and mitochondrial dysfunction are believed to contribute to neurodegenerative disorders, including Alzheimer disease (AD). In patients suffering from non-hereditary AD, UBB(+1), the frameshift variant of ubiquitin B, accumulated in neurons affected by neurofibrillary tan...

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Detalles Bibliográficos
Autores principales: Braun, Ralf J., Sommer, Cornelia, Leibiger, Christine, Gentier, Romina J., Dumit, Verónica I., Paduch, Katrin, Eisenberg, Tobias, Habernig, Lukas, Trausinger, Gert, Magnes, Christoph, Pieber, Thomas, Sinner, Frank, Dengjel, Jörn, Leeuwen, Fred W. v., Kroemer, Guido, Madeo, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348975/
https://www.ncbi.nlm.nih.gov/pubmed/28357285
http://dx.doi.org/10.15698/mic2015.04.199

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