The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death in Trypanosoma brucei

Background: Trypanosoma brucei is a blood-borne, protozoan parasite that causes African sleeping sickness in humans and nagana in animals. The current chemotherapy relies on only a handful of drugs that display undesirable toxicity, poor efficacy and drug-resistance. In this study, we explored the u...

Descripción completa

Detalles Bibliográficos
Autores principales: Koh, Hazel X., Aye, Htay M., Tan, Kevin S. W., He, Cynthia Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349101/
https://www.ncbi.nlm.nih.gov/pubmed/28357304
http://dx.doi.org/10.15698/mic2015.08.217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349101/
https://www.ncbi.nlm.nih.gov/pubmed/28357304
http://dx.doi.org/10.15698/mic2015.08.217

Ejemplares similares