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The lysosomotropic drug LeuLeu-OMe induces lysosome disruption and autophagy-independent cell death in Trypanosoma brucei

Background: Trypanosoma brucei is a blood-borne, protozoan parasite that causes African sleeping sickness in humans and nagana in animals. The current chemotherapy relies on only a handful of drugs that display undesirable toxicity, poor efficacy and drug-resistance. In this study, we explored the u...

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Detalles Bibliográficos
Autores principales:	Koh, Hazel X., Aye, Htay M., Tan, Kevin S. W., He, Cynthia Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Shared Science Publishers OG 2015
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349101/ https://www.ncbi.nlm.nih.gov/pubmed/28357304 http://dx.doi.org/10.15698/mic2015.08.217

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