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Rewiring yeast acetate metabolism through MPC1 loss of function leads to mitochondrial damage and decreases chronological lifespan

During growth on fermentable substrates, such as glucose, pyruvate, which is the end-product of glycolysis, can be used to generate acetyl-CoA in the cytosol via acetaldehyde and acetate, or in mitochondria by direct oxidative decarboxylation. In the latter case, the mitochondrial pyruvate carrier (...

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Detalles Bibliográficos
Autores principales: Orlandi, Ivan, Pellegrino Coppola, Damiano, Vai, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shared Science Publishers OG 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349135/
https://www.ncbi.nlm.nih.gov/pubmed/28357219
http://dx.doi.org/10.15698/mic2014.12.178