Applying a high-throughput fluorescence polarization assay for the discovery of chemical probes blocking La:RNA interactions in vitro and in cells

The RNA-binding protein La is overexpressed in a number of tumor tissues and is thought to support tumorigenesis by binding to and facilitating the expression of mRNAs encoding tumor-promoting and anti-apoptotic factors. Hence, small molecules able to block the binding of La to specific RNAs could h...

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Detalles Bibliográficos
Autores principales: Sommer, Gunhild, Fedarovich, Alena, Kota, Venkatesh, Rodriguez, Reycel, Smith, Charles D., Heise, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349447/
https://www.ncbi.nlm.nih.gov/pubmed/28291789
http://dx.doi.org/10.1371/journal.pone.0173246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349447/
https://www.ncbi.nlm.nih.gov/pubmed/28291789
http://dx.doi.org/10.1371/journal.pone.0173246

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