Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism

Disease associated genetic variations often cause intracellular enzyme inactivation, dysregulation and instability. However, allosteric communication of mutational effects to distant functional sites leading to loss-of-function remains poorly understood. We characterize here interdomain site-to-site...

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Detalles Bibliográficos
Autores principales: Medina-Carmona, Encarnación, Neira, Jose L., Salido, Eduardo, Fuchs, Julian E., Palomino-Morales, Rogelio, Timson, David J., Pey, Angel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349528/
https://www.ncbi.nlm.nih.gov/pubmed/28291250
http://dx.doi.org/10.1038/srep44532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349528/
https://www.ncbi.nlm.nih.gov/pubmed/28291250
http://dx.doi.org/10.1038/srep44532

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