Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP

Aβ peptide that accumulates in Alzheimer’s disease brain, derives from proteolytic processing of the amyloid precursor protein (APP) that exists in three main isoforms derived by alternative splicing. The isoform APP695, lacking exons 7 and 8, is predominately expressed in neurons and abnormal neuro...

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Detalles Bibliográficos
Autores principales: Fragkouli, Apostolia, Koukouraki, Pelagia, Vlachos, Ioannis S., Paraskevopoulou, Maria D., Hatzigeorgiou, Artemis G., Doxakis, Epaminondas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349543/
https://www.ncbi.nlm.nih.gov/pubmed/28291226
http://dx.doi.org/10.1038/srep44507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349543/
https://www.ncbi.nlm.nih.gov/pubmed/28291226
http://dx.doi.org/10.1038/srep44507

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