Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach

Discovering biased agonists requires a method that can reliably distinguish the bias in signalling due to unbalanced activation of diverse transduction proteins from that of differential amplification inherent to the system being studied, which invariably results from the non-linear nature of biolog...

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Detalles Bibliográficos
Autores principales: Onaran, H. Ongun, Ambrosio, Caterina, Uğur, Özlem, Madaras Koncz, Erzsebet, Grò, Maria Cristina, Vezzi, Vanessa, Rajagopal, Sudarshan, Costa, Tommaso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349545/
https://www.ncbi.nlm.nih.gov/pubmed/28290478
http://dx.doi.org/10.1038/srep44247

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349545/
https://www.ncbi.nlm.nih.gov/pubmed/28290478
http://dx.doi.org/10.1038/srep44247

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