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Systematic errors in detecting biased agonism: Analysis of current methods and development of a new model-free approach
Discovering biased agonists requires a method that can reliably distinguish the bias in signalling due to unbalanced activation of diverse transduction proteins from that of differential amplification inherent to the system being studied, which invariably results from the non-linear nature of biolog...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349545/ https://www.ncbi.nlm.nih.gov/pubmed/28290478 http://dx.doi.org/10.1038/srep44247 |