SLX4 Prevents GEN1-Dependent DSBs During DNA Replication Arrest Under Pathological Conditions in Human Cells

SLX4 is a versatile protein serving as docking for multiple structure-specific endonucleases during DNA repair, however, little is known about its function at demised replication forks. Using RNAi or FA-P cells complemented with SLX4 mutants that abrogate interaction with MUS81 or SLX1, we show that...

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Detalles Bibliográficos
Autores principales: Malacaria, Eva, Franchitto, Annapaola, Pichierri, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349550/
https://www.ncbi.nlm.nih.gov/pubmed/28290553
http://dx.doi.org/10.1038/srep44464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349550/
https://www.ncbi.nlm.nih.gov/pubmed/28290553
http://dx.doi.org/10.1038/srep44464

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