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Hsp90 dependence of a kinase is determined by its conformational landscape

Heat shock protein 90 (Hsp90) is an abundant molecular chaperone, involved in the folding and activation of 60% of the human kinome. The oncogenic tyrosine kinase v-Src is one of the most stringent client proteins of Hsp90, whereas its almost identical homolog c-Src is only weakly affected by the ch...

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Detalles Bibliográficos
Autores principales: Luo, Qi, Boczek, Edgar E., Wang, Qi, Buchner, Johannes, Kaila, Ville R. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349555/
https://www.ncbi.nlm.nih.gov/pubmed/28290541
http://dx.doi.org/10.1038/srep43996